广东梅州平远县农村妇女张爱兰的孩子被检查出身患重度地中海贫血需要骨髓移植三十万手术费，每个月输血维持生命要五千元，她老公决定放弃孩子的治疗，无奈之下张爱兰不顾丈夫的阻拦给自己卧病瘫痪多年的母亲磕头挥泪告别离开家乡，骑着一辆有棚的三轮车离开了家乡，踏上了去往广州的艰难求生之路。贫困潦倒的张爱兰带着孩子流落街头，后遇上酒吧驻唱歌手宁雨冰。曾经也有过流落街头经历的宁雨冰对这对母子起了恻隐之心，决定帮助这对母子。于是他开始街头做义演，呼吁众多爱心人士捐款帮助这对母子。在众人的援手之下，终于筹齐了手术费，挽救了一条小生命。
思雅为给母亲医治绝症，在求婚的当夜与烧烤哥阿星分手，选择了古董商人年十旺。阿星感觉事有蹊跷，决定找思雅问个清楚，却在思雅家发现一个行迹可疑的“医生”。此人正是年十旺以思雅母亲私人护理医生的名义，安放在思雅家伺机盗窃祖传之宝——“颛顼乘龙飞天图”的盗贼。阿星的到来影响了他们盗取宝图的计划，由此引发了一场跌宕起伏的拯救爱情与国宝的故事！
A clever fortune-hunter with a penchant for murder does in his elderly, supposedly rich, wife and manages to get away with it. After an investigation results in a decision of 'accidental death', our crafty killer discovers that his late wife's 'fortune' is not what he thought it was. Driven to find another unsuspecting spouse; he discovers that his new bride, a widow, is no fool. When she tells him that she intends to keep her accounts separate from his, he is driven to contemplate murder once again
